Advanced therapeutics: revolutionising healthcare using cell and gene therapies

The human body is made up of cells which are primarily organised into tissues. Each cell contains nucleic acid, such as DNA, which contains the genetic information required for the cell to function. 

Recent innovations in cell and gene therapies allow these fundamental biological building blocks to be modified and manipulated to treat disease. Gene therapy seeks to alter the expression of a gene or to modify the biological properties of living cells for therapeutic use. Cell therapy involves placing new, healthy cells into the body, for example to replace failing cells or to carry out a particular therapeutic function. Tissues can be engineered to contain beneficial cells or to replace or regenerate damaged tissue. 

Important advances in gene editing, nucleic acid delivery methods (such as adeno-associated virus (AAV)), immunotherapy, chimeric antigen receptors (CARs) and T cell receptors (TCRs), CAR-expressing immune cells (such as CAR-T), cell culture technology, protein engineering, precision medicine and machine learning-approaches to drug discovery mean that halting and reversing disease, restoring damaged organs, and treating many previously-untreatable conditions is now a realistic goal. 

The first wave of cell and gene therapies (also known as ‘advanced therapy medicinal products’ (ATMPs) or ‘cellular and gene therapy products’) are already being used in the clinic with striking results, and the development of next-generation technologies holds even greater promise. Such technologies are attracting significant investment: companies developing cell and gene therapies received approximately 30% (>$15 billion) of global VC biotech funding in 2019-2021.

Mewburn Ellis are delighted to be working with businesses that are developing technologies across the full spectrum of advanced therapeutic products.

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Forward magazine issue 5

The Reluctant Gradualist 


Forward editor Caitlin Mackesy Davies learns how we might all be able to live long and prosper from one of the world’s foremost investors in innovation

Billionaire investor and author Jim Mellon describes his involvement in the longevity technology sector as a matter of ‘happenstance’.

As he tells me on a Monday morning Zoom call, one of his long-time partners – with whom he has set up a number of biotech companies over the past 15 years – has always been interested the question of extending the human lifespan. It was this connection that led Mellon to ‘become aware that the science of longevity was catching up with the aspiration of all of us to live healthier and possibly longer lives’.

Read the full article here

Meet our advanced therapeutics team


Associate, Patent Attorney


Senior Associate, European Patent Attorney

Adam Gregory - Oct 2022

Partner, European Patent Attorney

Anna Mudge Feb-21

Senior Associate, European Patent Attorney


Partner, Patent Attorney, Litigator

Eliot Ward

Partner, European Patent Attorney

Laura Carney

Associate, Patent Attorney